Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Zurück zum Zitat H. Pisharath et al. The common fruit fly, Drosophila melanogaster , is a well studied and highly tractable genetic model organism for understanding molecular mechanisms of human diseases. Nat Rev Genet. 5, pp. Science 282:1711–1714 PubMed CrossRef Google Scholar. Many basic biological, physiological, and neurological properties are conserved between mammals and D. melanogaster , and nearly 75% of human disease-causing genes are believed to have a functional homolog in the fly. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. Animal models of human disease: zebrafish swim into view. Animal models of human disease zebrafish swim into view • First, human pathogens cause disease at 37°C, whereas zebrafish are maintained at 28°C; it might not be possible, therefore, to study some pathogens at this lower temperature. There is currently an unmet need for a therapy that promotes the regenerative process of remyelination in central nervous system diseases, notably multiple sclerosis (MS). ZFIN has responded to the increased use of zebrafish for translational research and the need to access human disease-relevant data by annotating zebrafish models of human disease as well as by providing dedicated user interfaces and search platforms to access human disease information. This review investigates the current state of nutrigenomics in the zebrafish animal models. View Article Google Scholar 21. Curr Opin Drug Discov Devel. (2005). Looking at the cerebral vasculature, the zebrafish develop thin-walled vessels that are prone to hemorrhage, reminiscent of what is seen in pathologic human lesions. Zebrafish share >70% genetic similarity with humans and many physiological processes and biological pathways are conserved between zebrafish and humans ( Burgess, 2013 ; MacRae and Peterson, 2015 ). 8 (5), 353–367 (2007) CrossRef PubMed. Zebrafish forward genetic screens: powerful approaches to identify new players in hematopoiesis. The zebrafish, Danio rerio, has emerged as a leading vertebrate model organism to study human diseases and biological effects of various chemicals (Lieschke and Currie, 2007). The zebrafish (Danio rerio) has been widely utilised for the study of developmental biology, which has lead to the evolution of sophisticated cellular and molecular approaches. Animal models of human disease are critically important to biomedical research. Currie, Animal models of human disease: zebrafish swim into view. The use of animal testing is still necessary. Animal models of human disease: zebrafish swim into view. - PubMed Voelker D, Vess C, Tillmann M, Nagel R, Otto GW, et al. Genet. Altmetric Badge. The zebrafish reference genome sequence and its relationship to the human genome. Marta Prat Coll The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding to include human disease. For specific models of human disease, Simon Festing adds, the farther away from the human species the animal studies get, the less predictive the model will be. A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Genet. For example, researchers studying some conditions, including Parkinson disease, have established a clear animal model. Effective targeted gene ‘knockdown’ in zebrafish. Lieschke GJ, Currie PD (2007) Animal models of human disease: Zebrafish swim into view. Cremediated site-specific recombination in zebrafish embryos. Rev. Insights into tuberculosis form the zebrafish model 18: 689-690 7.Lieschke G.J., et al. Nat Rev Genet. 4 Coagulation factors have been described in zebrafish, 5 their genes are identifiable in the zebrafish genome, 6 and hemostasis assays have been adapted to the model. ish,” and Lieschke and Currie (2007) said, “Animal models of human disease: zebrafish swim into view.” THE ZEBRAFISH GENOME The genome of zebrafish, a small freshwater vertebrate, consists of 25 chromosomes and contains essentially the full repertoire of vertebrate genes. So, most host–pathogen interactions that could be studied using this approach might be fish-specific. 8(5), 353–367 (2007).Crossref, Medline, CAS, Google Scholar; 21 Howe K, Clark MD, Torroja CF et al. (2002). Lieschke GJ, Currie PD. In this review, we provide a synopsis of nutrigenomics using the zebrafish animal model. Lieschke, P.D. The purpose of animal model usage is to understand a particular disease without causing risk to a human. (1998) Zebrafish hox clusters and vertebrate genome evolution. About this Attention Score In the top 25% of all research outputs scored by Altmetric. 1 Zebrafish have proven well-suited to large-scale genetic screening, whether in search of models for human disease or for control mechanisms related to natural or … The animals that are the most common models for human disease include, but are not limited to, the rat, mouse, and zebrafish. Lieschke GJ, Currie PD (2007) Animal models of human disease: zebrafish swim into view. (2000). Zebrafish (wild-type, Danio rerio) were maintained at 28°C in a 13 h light and 11 h dark cycle. Lieschke, P.D. These and other issues have prompted searches for alternative animal models to study heritable diseases. Nat. Progress in gene targeting has allowed for genetic modification of new animal species, which has greatly facilitated the study of disease processes that are poorly modeled in mice. Nat Rev Genet 8:353–367 PubMed CrossRef Google Scholar. Nature 496(7446), 498–503 (2013). 8. Cosma C.L., et al 2006. In this context, Vanchieri (2001) suggested, “Move over mouse: make way for the woodchucks, ferrets and zebrafish,” and Lieschke and Currie (2007) stated, “Animal models of human disease: zebrafish swim into view.” Nat. Traditional biotechnology in animal models included the mixtures of random genes. Animals that are chosen to model human diseases will often have similar physiology or some other similar aspect relating to human genetics. The zebrafish (Danio rerio) is used as a model vertebrate in developmental biology and for modeling human disease. The strong correlation between the embryonic zebrafish and developmental rat/rabbit studies could be readily anticipated as zebrafish is widely documented to rival or exceed the utility of rodents for the modeling of a growing list of human diseases (Lieschke and Currie, 2007; Santoriello and Zon, 2012; Scholz, 2013). There are many different animal models, ranging from flies to monkeys to mice, which are used to investigate human disease. The zebrafish is increasingly being used for the functional annotation of human disease genes as well as to model the cellular and molecular mechanisms underlying pathological processes. The zebrafish animal model has been used extensively in the study of disease onset and progression and associated molecular changes. 2003;6:218–223. 8, no. This review highlights the achievements and potential of zebrafish for modelling human cancer and for peptide … Zebrafish: from disease modeling to drug discovery. Zurück zum Zitat G.J. Animal models of human disease: zebrafish swim into view. Zebrafish Animal Model. View Article Genet. Zebrafish models based on known disease mechanisms have been developed in several therapeutic areas, including blood diseases, diabetes, muscular dystrophy, neurodegenerative disease, angiogenesis and lipid metabolism. 7 With large numbers of offspring and rapid external early development, the zebrafish is compatible with … Zebrafish (Danio rerio) are increasingly used to address key questions raised in basic and applied research including, but not limited to, biomedicine, toxicology, environmental science, biotechnology and aquaculture. 8. 4 Coagulation factors have been described in zebrafish, 5 their genes are identifiable in the zebrafish genome, 6 and hemostasis assays have been adapted to the model. 353–367, 2007. The zebrafish (Danio rerio) is used as a model vertebrate in developmental biology and for modeling human disease. 7. Overview of attention for article published in Nature Reviews Genetics, May 2007 . Although the in vitro cell cultures tests are widely used, the results may not generate actual forecasts compared with in vivo results. Hollway GE, Bryson-Richardson RJ, Berger S, Cole NJ, Hall TE, Currie PD. 2007 May;8(5):353-67. doi: 10.1038/nrg2091. Nat. 8(5), 353–367 (2007) CrossRefPubMed G.J. Zebrafish and frog models os Mycobacterium marinum infection Unit 10B.2. ... Rubinstein AL. Animal models have been an invaluable means to advance biomedical research as they provide experimental avenues for cellular and molecular investigations of disease pathology. Research often utilizes patients’ cells or tissue samples, but to determine if a mutation in a specific gene can cause a patient’s symptoms, we often need experimental animal models. Currie, Animal models of human disease: zebrafish swim into view. Scientists use a variety of laboratory techniques to investigate the genetic cause of human diseases. Rev. As a model of whole organism, zebrafish provide a means to develop promising peptide and protein anticancer agents in an informative, cost-effective and time-efficient manner, which also allows for surveying mechanisms of drug action and optimization of drug delivery system. Nat Rev Genet 8: 353–367. Barut BA, Zon LI (2000) Realizing the potential of zebrafish as a model for human disease. 95, 97 The experience with CCM modeling in zebrafish is one of the leading examples of how cerebrovascular disease can be studied in animal models. Zebrafish are known by their latin name, “ Danio rerio”. A high-throughput model is, therefore, required to screen potential therapeutic drugs and to refine genomic and proteomic data from MS lesions. Postlethwait JH, Yan YL, Gates MA, et al. Physiol Genomics 2: 49–51. 2007;8:353–367. The zebrafish (Danio rerio) is a good alternative to mammalian models that can be used to apply powerful genetic experimental methods normally used in invertebrates to answer questions about vertebrate … 2007 Animal models of human disease: zebrafish swim into view. While zebrafish have for some time been regarded as a powerful model organism with which to study early events in hematopoiesis, recent evidence suggests that it also ideal for unraveling the molecular requirements for T cell development in the thymus. ... Cre/ lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Rev. More recently, the rapid progress of various zebrafish genomic infrastructure initiatives is facilitating the development of zebrafish models of human disease. Modeling of congenital human disease in animals is key to our understanding of the biological mechanism underlying pathological processes and thus developing novel potential treatment options. 17. 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