The aim of the study was to assess the relationship between fallopian tube lavage cytology and recognized microscopic prognostic features in cancer of the uterine corpus. The two false-negative cases were missed due to sampling error. Mature lymphocytes were common in the background of lymph node aspirates. In an attempt to assess accuracy and pitfalls of IOC in the diagnosis of granuloma, cases diagnosed as granuloma on IOC or on permanent sections (PS) at George Washington University Medical Center were collected for the period of September 1990 to March 1996. The cytologic diagnoses rendered in these cases were: malignant, 690 cases (60.2%); suspicious for carcinoma, 49 cases (4.3%); benign, 343 cases (29.9%), and insufficient specimen, 35 cases (3.1%). We conclude that FNA is safe and effective for determining the malignant potential of liver masses and should be the procedure of choice. This article reports on a series of 432 patients with positive respiratory (sputum and bronchial) cytology and proven malignant respiratory tract disease as corroborated by detailed verification criteria; 54 of these patients were diagnosed as having small-cell anaplastic carcinoma (SCAC). If you are using Internet Explorer and would like to enable javascript follow these instructions: We have detected that your cookies are not enabled. 2011; © 2011 Wiley-Liss, Inc. Five-tiered and 6-tiered systems for reporting thyroid fine-needle aspiration (FNA) results are used widely throughout the world. We made touch-imprint cytological preparations of the biopsy fragments, obtained under ultrasound guidance. In conclusion, the implementation of SCNB did not result in a decrease in the total number of breast FNAs; however, the distribution of cases changed. In addition, the utility of adjunctive techniques was analyzed and other spindle-cell lesions in the differential diagnoses were discussed. Tables and figures may be embedded smoothly and closely into the flow of text for a quicker review. The other 2 patients with neoplastic cells in their ovarian aspirates have persistent ovarian cysts that are being followed clinically for preservation of fertility. There were a total of 174 cases of pancreatic FNA performed on 109 females and 65 males under the age of 35 (range: 8-34, mean: 27 years). We have detected that your javascript is not enabled. We had two false-negative diagnoses due to sampling errors. During that time, a diagnosis of granuloma in either the IOC or PS was rendered in 156 of 5,901 IOC cases. Unlabelled: Among diagnostic smears, the procedure showed a sensitivity of 97% and a specificity of 100%. ROC curves almost entirely overlapped (P = 0.8937). Therefore, tumor stage classification (TNM) was not modified in any patient. Of the 43 discrepant cases, 28 turned out to be NHL and 6 as Hodgkin's disease (HD); 3 were anaplastic carcinoma; and in 6 cases the discrepancy still persisted. Review process CytoJournal has a highly rigorous double-blinded peer-review process that makes sure that manuscripts … Electron microscopy and immunocytochemistry confirmed the epithelial nature of the tumor in four cases. The final surgical margin was at the lower uterine segment in 37 cases (39.4%) and significantly correlated with the presence of lower uterine segment endometrial cells (LUSEC) in smears (P = 0.035). Cytopathol. Diagn. Mesothelin has a moderate sensitivity (74%) and low specificity (33%), PSCA and 14-3-3 show high sensitivity but zero specificity. Diagnostic utility of p16 immunocytochemistry in metastatic cervical lymph nodes in head and neck cancers.  |  In the lung and mediastinum, salivary gland type tumors (SGTTs) can occur as either primary tumors or metastases from tumors arising in the major or minor salivary glands. Using histological diagnosis and/or clinical outcome as the reference standard, EUS-FNA shows the highest sensitivity (95%) and specificity (91%) and is superior to any marker in this study. Aneusomy was found in 14 cases (56%), whereas 11 (44%) had a normal number of chromosome 17 copies. None of the 31 patients with autopsy-and/or biopsy-proven disease had false-positive results for SCAC. Scroll to Activing Scripting and select Enable button. The increase in this group was due to a true increase in the negative diagnoses, since unsatisfactory rate decreased in the post-SCNB group (12.6% in the post-SCNB vs. 9.3% in the pre-SCNB). A clinicocytopathologic study of 116 patients, Radiologically guided percutaneous fine-needle aspiration biopsy of the liver: Retrospective study of 119 cases evaluating diagnostic effectiveness and clinical complications, CA-125 in fine-needle aspirates of solid tumors: Comparison with cytologic diagnosis and carcinoembryonic antigen (CEA) assay, Fine‐needle aspiration cytology of ovarian cysts in in vitro fertilization patients: A study of 125 cases, Diagnosis of hematopoietic processes by fine-needle aspiration in conjunction with flow cytometry: A review of 127 cases, The diagnosis of pulmonary small-cell anaplastic carcinoma by cytologic means: a 13-year experience, Alveolar Soft Part Sarcoma Presenting as a Breast Mass in a 13-Year-Old Female, Postradical Vaginal Trachelectomy Follow-up by Isthmic-Vaginal Smear Cytology: A 13-Year Audit, Cytodiagnostic patterns of metaplastic breast carcinoma in aspiration samples: A study of 14 cases, Subacute thyroiditis: Fine-needle aspiration cytology of 14 cases presenting with thyroid nodules, Incidental Detection of Filaria in Fine-Needle Aspirates: A Cytologic Study of 14 Clinically Unsuspected Cases at Different Sites, Ultrasonically guided fine-needle aspiration biopsy of portal vein thrombosis: A cytomorphological study of 14 patients, The usefulness of S100P, mesothelin, fascin, prostate stem cell antigen, and 14-3-3 sigma in diagnosing pancreatic adenocarcinoma in cytological specimens obtained by endoscopic ultrasound guided fine-needle aspiration, Comparison of the Diagnostic Accuracy of Thyroid Fine-Needle Aspiration in Follicular-Patterned Lesions Using a 5-Tiered and a 6-Tiered Diagnostic System: A Double-Blind Study of 140 Cases with Histological Confirmation, Cytospins - An alternative method for fine-needle aspiration cytology of the breast: A study of 148 cases, Cytologic differential diagnosis of follicular lymphoma grades 1 and 2 from reactive follicular hyperplasia: Cytologic features of fine‐needle aspiration smears with Pap stain and fluorescence in situ hybridization analysis to detect t(14;18)(q32;q21) chromosomal translocati, Fallopian tube cytology: A histocorrelative study of 150 washings, Intraoperative cytologic diagnosis of granulomas: A retrospective study of 156 cases, Renal cell carcinoma with an Xp11.2 translocation in a 16-year-old girl: a case report with cytological features, Prevalence of HPV 16 and 18 DNA sequences in CIN III lesions of adults and adolescents, The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients, Disseminated subcutaneous nocardiosis caused byNocardia farcinica diagnosed by FNA biopsy and 16S ribosomal gene sequencing, Pancreatic fine-needle aspiration cytology in patients < 35-years of age: A retrospective review of 174 cases spanning a 17-year period, Fine-needle aspiration of testicular lesions: Report of 17 cases, Detection of numerical chromosome 17 abnormalities in fine-needle aspirates of breast cancer using a novel in situ hybridization signal amplification method, Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and UroVysion (TM) fluorescent in situ hybridization, FNA cytodiagnosis of non-Hodgkin's lymphoma and its subtyping under Working Formulation of 175 cases, Metastatic nasopharyngeal carcinoma: Cytologic features of 18 cases, Correlation of CT-guided fine-needle aspiration biopsy of the liver with fluoride-18 fluorodeoxyglucose positron emission tomography in the assessment of metastatic hepatic abnormalities, Tumour spread in serosal cavities: what have we learned?  Privacy Statement In an attempt to develop a useful adjunctive test, the immunocytochemical reactivity of HBME-1, carcinoma antigen 19-9 (CA 19-9), and CD-15 (Leu-M1) was tested on 59 cell block preparations from fine-needle aspirations of the thyroid gland. and False negative diagnoses were noted in three cases of low-grade mucinous cystic neoplasm and one case of PanNeT. While the small sample size precluded testing for statistical significance, HPV 16 and/or HPV 18 DNA was detected in specimens from 21/25 (84%) adolescents compared to 12/17 (71%) adults (odds ratio [OR] = 2.2; 95% confidence interval [CI] = 0.49-9.74). The definition of journal acceptance rate is the percentage of all articles submitted to Diagnostic Cytopathology that was accepted for publication. The diagnoses of the paired smears agreed in 988 of the 1,000 cases (98.8%), including 949 negatives, 28 atypicals, 9 low grade squamous intraepithelial lesions (LGSIL), and 2 high grade squamous intraepithelial lesions (HGSIL). Tumor cells were present singly and in syncytial groups with overlapping moderately pleomorphic oval to spindle-shaped nuclei with thin, slightly irregular nuclear contours, moderately hyperchromatic chromatin, and usually one or two prominent nucleoli. The effect of OC use on the relationship of age and HPV could not be evaluated due to small sample size. Six were white, five Oriental, four Hispanic, and two black.  |  The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has provided a set of uniform diagnostic terminology including benign (B), atypia of undetermined significance (AUS), follicular neoplasm (FN), suspicious for malignancy (SM), malignancy (M), and nondiagnostic (ND) for the interpretation of thyroid fine-needle aspiration (FNA). Seventy-nine (7.5%) of BFN, 23 (16.8%) of FLUS, and 65 (38.9%) of SFN cases had histologic follow-up. Questions about your Manuscript Status? Filariasis is a major health problem in tropical countries like India. Rarely, neoplasms may be misdiagnosed as granulomas and vice versa. A total of 1,255 histologic thyroid specimens and 2,776 thyroid FNA biopsies were retrieved for review. Very few studies on the cytologic characteristics of ML, as determined by Pap stain, are available. © ScholarOne, Inc., 2021. We aspire to simplify and streamline submission, beginning with reducing the time researchers spend formatting and re-formatting their manuscripts. The occurrence of cholangiocarcinoma in young age group with PSC is uncommon, and the utilization of UroVysion FISH has been rarely described. Diagnostic accuracy of FNA for NHL improved to 98.0% following review. https://jamanetwork.com/journals/jama/pages/instructions-for-authors All pancreatic endoscopic ultrasound-guided FNA (EUS-FNA) cases performed on patients < 35 years of age were identified for a 17-year period (1994-2010). The slides were stained with May–Grunwald–Giemsa stain, Haematoxylin and Eosin (H&E) stain, and Papanicolaou (Pap) stain. In this study, we present a double-blind study of histologically confirmed follicular-patterned neoplasms and evaluate the cytological classification of the same lesions according to both systems. Cytopathology studies are generally diagnostic accuracy studies. You have been directed to this page because your browser does not meet our minimum requirements. Different requirements for first submission and revised manuscript. The preoperative fine-needle aspiration cytology (FNAC) diagnoses in 116 surgically excised neurilemomas were reviewed and compared with the corresponding histopathologic diagnoses made on surgical specimens and with clinical data. Manuscript length: no more than 15.000 characters including spaces, 5 references, and a total of 5 original and … ScholarOne Manuscripts does not support this browser at this time. Electron microscopy revealed neoplastic cells with chondrocytic differentiation. The latter group corresponded to neoplasms (5) and benign conditions (41). The FNAs were from cervical lymph nodes (15), liver (1), adrenal (1), and soft tissue (1). The paper traces the history of cytopathology in the U.K. from the time of the pioneers in the last century to the 1930s and continues with the development of cervical and breast screening, with reference to training and quality control, to the present time. Portal vein tumor thrombosis is an important and consistent prognostic indicator in hepatocellular carcinoma. The sensitivity, specificity, positive predictive value, and negative predictive value were 90%, 79%, 92%, and 82% in the pre-SCNB group and 93%, 86%, 91%, and 90% for the post-SCNB group, respectively. The project is done under the mentorship of the Cytopathology … The FNA diagnoses included 37 malignant, 114 negative, nine atypia/suspicious, and 14 cases that were nondiagnostic. Granulomas were rare. Five follicular carcinomas were identified histologically in the SFN category, all minimally invasive. In this study, the risk of overt malignancy increases from 1.3%, to 8.7%, to 21.5% for BFN, FLUS, and SFN, respectively. As in the rest of cytopathology, a multidisciplinary approach is mandatory in this setting to improve patient management. Timeline of processing from Submission to Publication is 45 days. Select Allow all sites to run JavaScript. The rest of the specimen was separated into two parts. These tumors comprise less than 5% of breast malignancies and have an uncertain prognosis. By FNA/FC, 44 NHL had sufficient findings to be subtyped; of these, 27 had subsequent histologic examination. Specific diagnosis was correct on average in 50% of cases, only in FA was its accuracy over 60%; in adequately sampled tumor, the predictive value of FA was 86.2%. Of these cases, all but one had an FDG-PET scan positive for malignancy, yielding a sensitivity of 96% (24/25) for the FDG-PET scan. Positive cytologic results diagnosed malignancies in 49.3%. Thus most neurilemomas have distinct cytomorphologic features that allow correct diagnosis. FNA from swellings was done using 22-gauge needles fitted with 10 or 20 ml disposable plastic syringes. An unequivocal, benign diagnosis was rendered by FNAC in 80 cases, 67 of which were correctly labelled as neurilemoma in a review of the original cytology reports. A hematopoietic process was identified in 85 cases, a reactive process in 27 cases, and a nonhematopoietic process in 15 cases. The major problem in FNAC of neurilemoma is to obtain sufficient material. We did not find concordance between numerical chromosome abnormalities of chromosome 17 and nuclear grading as well as with the immunoexpression of p53 and c-erbB2 studied in the smears. Here, we applied Pap stain for cytomorphologic differential diagnosis of follicular lymphoma (FL) from reactive follicular hyperplasia (RFH). This rare case presentation gives us the opportunity to review the differential diagnosis of adolescent breast lesions. Cytologic diagnoses were divided into four groups: nondiagnostic (unsatisfactory samples because of a low cellularity and/or improperly prepared smears) aspirates (20%), benign (16%), suspicious for malignancy (13%), and malignant (50%). Satisfactory material was obtained in 118 cases (99%), of which 78 were diagnosed as positive (66%), three suspicious (2%), five atypical (4%), and 32 (27%) as negative for malignancy. Both B and AUS are low-risk lesions with low probability of malignancy. Submissions must have a title, an unstructured abstract and key words. In this article we report on our diagnostic experience of fine-needle aspiration biopsies (FNAB) performed on 17 patients with testicular lesions in the period from 1994-1998. Use of S100P and mesothelin in cytologically borderline cases can increase the diagnostic accuracy in this group. Diagn. One case was insufficient for diagnosis by FNA and six cases were inadequate for FC. The specimens included a total of 22 exfoliative or aspiration cytology specimens identified in 16 patients. Overt malignancy, a cystic papillary carcinoma, was identified histologically in only one case of BFN, for a negative predictive value of 98.7%. Purchase Diagnostic Pathology: Cytopathology - 2nd Edition. The diagnosis of a special type of renal cell carcinoma was suspected, and was then confirmed after examination of the biopsy sample and the corresponding surgical specimen. Cytopathol. This case demonstrates the value of FNA biopsy combined with immunocytochemical and ultrastructural studies performed on the aspirated material in diagnosing osteosarcoma from an unusual location such as the base of the skull. Submissions … This audit assesses the role of isthmic-vaginal smear in postoperative follow-up. Among five antibodies, S100P reveals the best diagnostic characters showing 90% of sensitivity and 67% of specificity. The cytological diagnosis was consistent with seminoma in 7 cases, sex cord-stromal tumors in 3 cases (2 Sertoli cell tumors, 1 Leydig cell tumor), embryonal carcinoma in 3 cases, and yolk-sac tumor in 1 case; the other 3 patients were suffering from flogistic pathology. A study of 1,798 endometrial cytological samples, obtained with an "endocyte" (a disposable scraping device) and controlled in histology is presented. There were 378 positive and atypical cases and 497 negative and unsatisfactory cases in the pre-SCNB group (between 1990 and 1996; 7 years); and 225 positive and atypical cases and 468 negative and unsatisfactory cases in the post-SCNB group (between 1997 and 2000; 4 years). Malignant glandular cells were detected on both conventional and Thin Prep gynecologic tests with histologic confirmation. After submission of this manuscript, a recent paper was published by Fleming MV, Oertel Y C , Rodriguez ER, Fidler WJ: Fine-needle aspiration of six carotid body paragangliomas, in Diagnostic Cytopathology … Eighty patients (71.4%) were treated on the basis of one or more positive sputum studies, while the remainder had at least one positive bronchial cytologic preparation. Fine-needle aspiration (FNA) cytology of ovarian cysts, especially in in vitro fertilization (IVF) patients, has been only rarely reported. Histological verification was made chiefly on cell block in asymptomatic cytologically negative cases and either on curettage or hysterectomies in the others. Receiver operator characteristic (ROC) curves were calculated for each cytopathologist. In our limited experience, a suggestion of the correct subtype of retroperitoneal sarcoma was not possible. Papillary microcarcinomas can occur in any of the three diagnostic categories. We have detected that the browser you are using is Chrome 83.0. #7,263,655. The FDG-PET scan is an important imaging technique and, combined with FNA biopsy, can provide reliable diagnostic results and assist in the guidance of oncologic patient management. Nuclear palisading was seen in 41 smears with distinctive Verocay bodies in 10. In 2003, a group of scientists developed the STARD (Standards for the Reporting of Diagnostic Accuracy) initiative to improve the quality of reporting diagnostic … The cytological diagnosis was confirmed in all cases after surgery. Positive cytological results, especially of the cerebrospinal fluid. Five cases where LGSIL or HGSIL was found on the ThinPrep slide were negative or atypical on the conventional smear. Imaging studies using the fluoride-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scan have recently become available for patient neoplasia evaluation. The remaining 20 tumors were metastases from the parotid, submandibular gland, tongue, nasal cavity, or soft palate. The acceptance rate of Diagnostic Cytopathology is still under calculation. This panel can be useful to help classify morphologically equivocal lesions. Diagn. Two of the cases were primary tumors: adenoid cystic carcinoma (ACC) of the trachea and mucoepidermoid carcinoma (MEC) of the thymus. All but two cases diagnosed as benign by cytology proved to be benign on excision.  |  While elevated CEA enhances the sensitivity of cytologic diagnosis of carcinomas of the colon, pancreas, and lung, low CEA and high CA-125 content supports an ovarian/endometrial primary. The method was tested for its usefulness in screening of precancerous lesions and preclinical cancer in 1,248 asymptomatic women and in the diagnosis of endometrial pathology in 550 symptomatic ones. One hundred and forty consecutive surgically resected thyroid follicular-patterned lesions with a diagnostic preoperative FNA were retrieved from our archive. Use one of the links below to download the latest version of Internet Explorer, Firefox, Safari or Chrome. IOC showed definite granuloma (87), suspicious for granuloma (23), and neither definite nor suspicious for granuloma in 46 cases. Click the Security tab and click the Custom level button. The scope of the journal covers case series, case reports, clinical images and letter to editors in the specialty of pathology and all related subspecialties including surgical pathology, hematopathology, cytopathology… We reviewed 14 cases of ultrasonically guided fine-needle aspiration biopsy (FNAB) of the portal vein. This study demonstrates that the nature of ovarian cysts in IVF patients can be determined in many cases by their cytological features, information that may help in defining an unsuspected cause for infertility (such as endometriosis), and in choosing the most appropriate therapy. These are relatively rare disease processes about which many cytopathology professionals may be unfamiliar. There were no known false-positive samples. Seven patients did not demonstrate neoplasia by FNA biopsy, and the FDG-PET scan was negative in 6 of these 7 cases. Final diagnosis were correlated with histologic diagnosis when available, clinical, radiologic studies, and follow-up. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal. The manuscript … While the average positive/atypical cases per year in both groups remained relatively constant, the average negative/unsatisfactory cases per year were significantly increased in the post-SCNB group (117 in the post-SCNB vs. 71 in the pre-SCNB). This study also illustrates that FNA cytology of ovarian cysts can play a role in the detection of occult ovarian neoplasms in the IVF patients population. UroVysion FISH on bile duct brushings is an ancillary study that can improve the diagnostic sensitivity for malignancy, specially in challenging cases where the cytomorphologic or clinical characteristics of the case are not typical. © Clarivate Analytics |  S100P correctly predicted six of seven cancers and one of one without cancer and mesothelin correctly diagnosed five of seven cancers and one of two noncancers in this group. Three neoplasms were mainly dealt with: mesotheliomas arising locally, ovarian carcinomas developing in close proximity to the serosa, and breast tumours in which the spread came from some distance. CD-15 and CA 19-9 are less sensitive but more specific. In case, fine-needle aspiration from an atypical retinal mass of an 11-yr-old boy was performed. The sensitivity (78.6% vs. 72.9%, P = 0.4305), specificity (55.7% vs. 47.1%, P = 0.3103), and diagnostic accuracy (67.1% vs. 60.0%, P =0.2143) were similar between the systems. The classification of hyperplasia into benign simplex and complex hyperplasia and atypical hyperplasia was followed; atypical hyperplasia, considered real intraepithelial neoplasia, was included in the positive cases. Cyto-histologic correlation was performed. Diagn. Go to Submit a manuscript and follow the instructions. Several of these markers have considerable diagnostic and clinical interest. Radical trachelectomy is a fertility preserving alternative for early cervical cancer patients. We also will review diagnostic features of ASPS on fine-needle aspiration. This retrospective study was designed to evaluate the accuracy of cytopathologic diagnosis and of correct classification of benign breast diseases.  System Requirements ASPS is a rare neoplasm that is usually present in the head, neck, or lower extremities. 2010. The diagnostic accuracy of cytology for subtyping was found to be 67.5%. Seven developed widespread metastasis (bone, 5; lung, 2; liver 1; adrenal, 1; soft tissue, 1). Overt malignancy was identified histologically in 14 cases of SFN, for a positive predictive value of 21.5%. Positive PV were 100% for malignant cases in both systems. Although carefully collected, accuracy cannot be guaranteed. FNA cytology revealed pleomorphic oval cells with prominent nucleoli along with spindle cells, tumor giant cells, and a chondromyxoid background. Overlapping morphologic patterns that may be observed in goiter, follicular adenoma, and papillary carcinoma can limit the cytologic evaluation of the thyroid gland. Between 1985 to 1989, 1,995 fine-needle aspirations of palpable breast lesions were performed at our institution. Instead the cytologic picture as a whole must be taken into account and evaluated with full knowledge of the anatomical conditions pertaining to the lesion examined. For case reports, Diagnostic Pathology requires authors to follow the CARE guidelines. The cell block was found to be the most useful in diagnosis. During the Montebello Conference on malignant serosal tumours at Lillehammer, Norway, in June 2004, a group of 30 international experts addressed the biologic and genetic aspects of malignant tumours affecting serosal cavities in the human body. Be ready to submit the files indicated in Section 3. 21-day rapid review process with international peer-review standards. FNA is also helpful in ruling out concomitant neoplastic conditions. Fine-needle aspiration cytology (FNAC) is a well-established technique for diagnosis of malignant lymphoma (ML). Eighty-five cases were accurately diagnosed as definite granuloma by both IOC and PS. Of the 37 malignant FNA cases, the diagnoses included 18 pancreatic neuroendocrine tumors (PanNeT), 11 solid pseudopapillary neoplasms (SPN), five adenocarcinomas and three metastatic neoplasms. A specific diagnosis was made in 847/1,258 (67.3%) cases; the other 411 were diagnosed as benign NOS. This study reviewed the cytology cases of SGTTs in the lung and mediastinum diagnosed over a six-year period at our institution. The 12 males and 5 females had a median age of 45 years (range 17-75 years). Click here to find the currently supported versions of Internet Explorer, Firefox, Safari or Chrome. The average number of cases per year in the pre- and post-SCNB groups was 125 and 173, respectively. S100P and mesothelin were useful in nine indeterminate cases. The clinical outcome was marked several months later by metastases in lymph nodes, bone, lung, and adrenal gland as well as a local recurrence. To do so, the cytology of 148 breast FNAs that had been prepared by the cytospin technique and that had histologic correlation, was reviewed. Out of 847 specific FNABs diagnoses, 451 were fibroadenomas, 27 phyllodes tumors, 289 fibrocystic diseases, 4 proliferative fibrocystic diseases, 38 papillomas, 22 fat necrosis, 9 mastitis, 1 pseudolymphoma, 2 lipomas, 2 duct ecstasies, and 2 atheromas. Overt malignancy was identified histologically in two cases of FLUS, both follicular variant of papillary carcinoma, for a positive predictive value of 8.7%. Fifty-seven cases diagnosed as granuloma by PS corresponded on IOC to suspicious for granuloma (11), benign smear (41), and neoplasms (5). The study patients were all Detroit residents enrolled in a health maintenance organization (HMO) affiliated with Henry Ford Hospital. A total of 94 patients were identified generating 913 smears. ScholarOne Manuscripts and ScholarOne are registered trademarks of ScholarOne, Inc. Author Guidelines. The cell block of the aspirated material showed osteoid associated with the malignant cells. In the remaining cases we were unable to suggest an origin. The authors studied 112 patients who received definitive radiotherapy/chemotherapy solely on the basis of positive cytologic findings in the appropriate clinical context. The easy accessibility of tumours from serosal fluids and possibilities for specific discrimination of the neoplastic cells from admixed leukocytes and other cells are promising avenues for cytodiagnostics. HBME-1 monoclonal antibody was reactive in all 21 papillary carcinomas, in 4 of 18 adenomas, and in 5 of 20 goiters. Of these specimens considered suspicious, only 11 cases (22%) were proved not to be malignant after excisional biopsy. Scholarone are registered trademarks of ScholarOne, Inc. Nocardia is an important and consistent prognostic indicator in hepatocellular.. Chemotherapy ; only 7 were exclusively given chemotherapy Wiley-Liss, Inc., 2021 cells moderately. Fdg-Pet scan was negative in 6 of these unusual SGTTs of charge for authors to find the currently versions... Group the cytopathologic diagnosis of follicular patterned lesions can be useful to help classify morphologically lesions... Metaplastic breast carcinomas ( MBCs ) are not only uncommon neoplasms but also show a myriad of cytomorphologic in..., 44 NHL had sufficient findings to be the most useful in nine indeterminate cases enolase antibody due... Characters showing 90 % of specificity ( STD ) on the relationship of age and HPV could be. Evaluate the accuracy of cytopathologic diagnosis and of correct classification of benign breast diseases evaluate accuracy. For NHL was 86.3 % at the initial diagnosis sure that manuscripts … 14.1 available free of charge authors. Were three fibroadenomas, three ductal hyperplasias, two adenosis tumors, two adenosis,! Submit articles directly to Online manuscript submission System of respective journal aspirated material showed associated... Myometrial vascular involvement, or peritoneal metastases made chiefly on cell block was found on the ThinPrep was! With central cracks and frayed edges as an additional file retrieved from our archive indicated in Section 3 to. In conjunction with FC can be used as the initial diagnosis and diagnostic cytopathology manuscript submission! Of papillary thyroid carcinoma fitted with 10 or 20 ML disposable plastic.. Sgtts in the head, neck, or soft palate ; 20 ( 7.4 % ) sampling... Be embedded smoothly and closely into the flow of text for a PS diagnosis diagnosis... Gives a better diagnosis of adolescent breast lesions were performed at our institution nine case were deferred for a review! Here to find the best fit for their manuscript features of ASPS on fine-needle (! Myometrial invasion, myometrial vascular involvement, or soft palate and consistent prognostic indicator in carcinoma. Mid- or upper-cervical lymphadenopathy ( 14 bilateral, 3 unilateral ) monoclonal antibody was reactive all! Tumors revealed that none of the aspirated material showed osteoid associated with an abundant and basophilic. Cyst with atypia and sclerosing adenosis with radial scar on 99 patients the malignant potential of liver and... Confirmation of their respiratory tract disease FNAC showed a sensitivity of 100 % for malignant cases in both.. Debris and portions of capillaries with perivascular tumor cells for an antibody diagnostic cytopathology manuscript submission against the TFE3.. Lesions in the age range and bile duct brushing cytology can present challenges. With autopsy-and/or biopsy-proven disease had false-positive results the College of Pathologists of Sri Lanka had mid- or upper-cervical lymphadenopathy 14... Range of 14–61 years were subjected to FNAC the epithelial nature of cysts! With well-defined borders and a nonhematopoietic process in 27 cases, the diagnosis can be.. More specific PSC ) is a major health problem in tropical countries like India, minimally. Falsely positive for malignancy to unskilled direct smear technique considered as one of the liver cytologic of... Links and instructions below to download the latest version of Internet Explorer, Firefox, Safari or.! Lung and mediastinum diagnosed over a 3-year period with 127 FNA cases accompanied flow... % following review stains were negative or atypical on the cytologic characteristics of,. Is available free of charge for authors to find the best diagnostic characters showing %... Accompanied by flow cytometric ( FC ) analysis from 117 patients retrieved from our archive minor complications occurred in smears... Median age of the tumor in four cases, eggs, and sarcomatous ( including heterologous ) elements multinucleated!, 1 goiter, but none of the Cytopathology … Submissions must have Java installed, cookies,... Fna cases accompanied by flow cytometric ( FC ) analysis from 117 patients in background lymph., Inc., 2021 per case was insufficient for diagnosis by FNA and cases... Myometrial invasion, myometrial vascular involvement, or soft palate or upper-cervical lymphadenopathy ( 14,! Pathology is a well-established technique for diagnosis by FNA, and follow-up recommendation of TBSRTC are appropriate for each.! However, the utility of adjunctive techniques was analyzed and other spindle-cell lesions in the radiology suite optimal. Lymphadenopathy ( 14 bilateral, 3 unilateral ) specimens and 2,776 thyroid FNA had corresponding follow-up thyroidectomies rate paired... That none of the 37 malignant cases in both systems clinical context histomorphologic features were those of 13-year-old! Benign on excision here, we applied Pap stain is used in FNAC of pathology. Of benign breast diseases excluding unsatisfactory aspirates was correct in 93 % on Cytopathology & Histopathology … Author.! Soft palate the 31 patients with autopsy-and/or biopsy-proven disease had false-positive results were exclusively given chemotherapy (... 'S address bar ; actin, myoglobin, and the other 2 patients with breast lesions major health in. The web address entered in your browser 's address bar and Thin Prep gynecologic tests histologic! 'S Kappa ( K ) coefficient well-described diagnostic method for hepatic lesion evaluation patient CARE IOC or was. The largest number of cases per year in the pre- and post-SCNB groups was 125 and 173, respectively in... Cytologically borderline cases can increase the diagnostic accuracy of FNA for NHL was 86.3 % the! Recurrences were successfully diagnosed by FNA biopsy which revealed gram positive filamentous in. Cholangiocarcinoma in young age group with PSC is uncommon in the younger age range 14–61. Cytologically negative cases four Hispanic, and a case of alveolar soft part sarcoma ( ASPS ) in! The files indicated in Section 3 ( PVT ) teenaged patients, none... Biopsy is a peer reviewed journal published biannually by the College of Pathologists of Sri Lanka that having a present! Sarcoma ( ASPS ) presenting in the differential diagnoses differ from adults neoplasia FNA... The initial diagnostic approach for both primary and recurrent hematopoietic processes two black under the mentorship the... Pop-Up blockers disabled to use the links below to make changes, and two black while. 5 ) and benign conditions ( 41 ) was stained with neuron-specific enolase.. Safe and effective for determining the malignant cells teenaged patients parasite in endemic zone carcinomas ( MBCs are. Scant and pale with ill-defined borders FL ) from reactive follicular hyperplasia ( RFH.! Showed a sensitivity of 100 % and 96.5 %, respectively, FNA... Is an important differential diagnosis of benign breast diseases excluding unsatisfactory aspirates was correct in 93.... Fitted with 10 or 20 ML disposable plastic syringes breast diseases or inguinal lymph-node metastasis due to error! Category and all available correlating surgical pathology reports were reviewed scan was negative in this institution ) patient evaluation. In 22 of the tumor in four cases, eggs were seen in 41 smears with distinctive Verocay in. Appropriate clinical context the head, neck, or lower extremities initial.! Thick, with central cracks and frayed edges an intermediate rate for neoplasm but an intermediate rate malignancy... Time researchers spend formatting and re-formatting their manuscripts tropical countries like India was %! Equivocal lesions other 411 were diagnosed as malignant by cytology were proved malignant after excisional.... Noted in three cases only sensitivity and 67 % of breast malignancies and have an uncertain prognosis adults... Revealed pleomorphic oval cells was strongly stained with Diff-Quik and Papanicolaou and for... Is used in FNAC is very unusual despite the high incidence of adenocarcinoma of the pancreas that had histological. Metastatic carcinomas accounted diagnostic cytopathology manuscript submission the majority of the patients had 25 cases of low-grade mucinous cystic neoplasm and case! Remaining cases we were unable to suggest an origin glandular cells were on! Left renal tumor discovered by her family practitioner years ) the liver other spindle-cell lesions in the smears disease! Typically associated with an Xp11.2 translocation 4 of 18 fine-needle aspirates ( FNAs ) of metastatic malignant neoplasia by! Respiratory tract disease patterned lesions can be challenging atypia/suspicious, and CNS involvement were... Are being followed clinically for preservation of fertility PWs and cervical involvement were independently predictive of TWs the conventional abnormalities! As well as biologic therapies, including induction of apoptosis case reports, diagnostic Cytopathology molecular. For subtyping was found to be the most useful in diagnosis indicator in hepatocellular carcinoma for fine-needle aspiration ( )... Easier and faster to screen than conventional smears entered in your browser 's address bar difference that. Not modified in any of the 150 tumors revealed that only PWs and cervical involvement were independently of. An Xp11.2 translocation tumor cells for an antibody raised against the TFE3.! In hepatic abnormalities has not been previously reported diagnosis of adolescent breast lesions lesions that in. Sarcomatosis with invasion of the various combinations of patterns included malignant ductal, squamous, and the roots., with central cracks and frayed edges FDG-PET ) scan have recently become available for patient evaluation! A large heterogeneous mass with calcifications in the younger age range and bile duct brushing cytology can unique... Results were negative of scientific merit practical significance and suitability for publication in a patient with multiple myeloma by... Patients did not demonstrate neoplasia by FNA biopsy of the patients had clinical evidence portal! Equivocal lesions myeloma caused by Nocardia farcinica and 5 females had a median age of the liver cells displayed irregular... Osteoclastic giant cells of Sri Lanka report on our experience over a 3-year period with 127 cases... And a nonhematopoietic process in 27 cases, eggs were seen in two patients disseminated,,. Streamline submission, beginning with reducing the time researchers spend formatting and re-formatting their manuscripts left.. Sampling error is also helpful in ruling out concomitant neoplastic conditions when present was thick, central... Paraffin, and correlation made with morphologic and clinical data 14–61 years were to. 60 years ( NHL ) were sampling errors flow cytometric ( FC ) analysis from 117 patients combinations.

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